Variations in the amount and distribution of phosphorylated compounds in ischemia and reactive hyperemia in the dog heart

Abstract

A study has been made of the concentration and location of phosphorylated compounds in serial myocardial biopsies taken from the left ventricle of dogs during and after brief coronary occlusion. Ischemia reduced the amount of phosphorylated substances, such as ATP and phosphocreatine. During reactive hyperemia these substances were lost into the intimate coronary circulation around the fibers. This raises the possibility that the leakage of such vasodilator substances from the myocardium into the vascular bed, either themselves or through their hydrolytic products, may account for the vasodilation of reactive hyperemia.