Variations in serum müllerian inhibiting substance between white, black, and Hispanic women

Abstract

To compare serum müllerian inhibiting substance (MIS) levels between white, black, and Hispanic women to determine whether ovarian aging occurs at a different time course for women of different racial groups. Longitudinal study of serum MIS levels in women of different race and ethnicity over two different time points. Women's Interagency HIV Study, a multicenter prospective cohort study. Serum samples obtained from 809 participants (122 white, 462 black, and 225 Hispanic women). Comparison of serum MIS between women of different race and ethnicity at two time points (median age 37.5 years and 43.3 years). Variation in MIS by race and ethnicity over time, controlling for age, body mass index, HIV status, and smoking. Compared with white women, average MIS values were lower among black (25.2% lower) and Hispanic (24.6% lower) women, adjusting for age, body mass index, smoking, and HIV status. There is an independent effect of race and ethnicity on the age-related decline in MIS over time.