Abstract
CONSIDEKATION of data which suggest that disturbances in regulation of body temperature, spontaneous locomotor activity, food intake and body weight can be produced by lesions of the hypothalamus led to proposal of the hypothesis that the hypothalamus is the level of the central nervous system most intimately concerned with integration and control of rates of energy exchange in mammals (Brobeck, 1945; Hare, 1946). The present series of experiments was designed indirectly to test the validity of this hypothesis. The experiments were based upon observations by Wang (1923) and Slonaker (1924), who found estrus in the rat to be associated with a pronounced increase in spontaneous locomotor activity, i.e., with a significant increase in energy expenditure. If the hypothesis proposed above is a valid one, the estral increase in motor output presumably arises from the hypothalamus, and one might expect to find estrus also to be accompanied by changes in food intake, body weight and body temperature, since whatev...
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