Abstract
Hypertriglyceridemia-associated acute pancreatitis (HTGAP) is linked with increased severity and morbidity. Intestinal flora plays an important role in the progression of acute pancreatitis (AP). However, pathogenetic association between gut microbiota and HTGAP remains unknown. In this study, we enrolled 30 HTGAP patients and 30 patients with AP that is evoked by other causes. The V3–V4 regions of 16S rRNA sequences of the gut microbiota were analyzed. Clinical characteristics, microbial diversity, taxonomic profile, microbiome composition, microbiological phenotype, and functional pathways were compared between the two groups. Our results showed that the HTGAP group had a higher proportion of severe AP (46.7% vs. 20.0%), organ failure (56.7% vs. 30.0%), and a longer hospital stay (18.0 days vs. 6.5 days). HTGAP group also had poorer microbial diversity, higher abundances of Escherichia/Shigella and Enterococcus, but lower abundances of Dorea longicatena, Blautia wexlerae, and Bacteroides ovatus as compared with non-HTGAP group. Correlation analysis revealed that gut bacterial taxonomic and functional changes were linked with local and systemic complications, ICU admission, and mortality. This study revealed that alterations of gut microbiota were associated with disease severity and poor prognosis in HTGAP patients, indicating a potential pathophysiological link between gut microbiota and hypertriglyceridemia related acute pancreatitis.
Highlights
This study aims to investigate the relationship between the changes of intestinal flora and the prognosis of Hypertriglyceridemia-associated acute pancreatitis (HTGAP) patients, and to lay a basis for future research and translation
We found that patients in the HTGAP group had a worse outcome than that those in the non-HTGAP group, and significant correlations existed between the altered intestinal microflora and prognostic markers, including disease severity, local and systemic complications, ICU admission, and mortality
We found that Blautia wexlerae, Bacteroides ovatus, and Dorea longicatena were positively correlated with microbial gene functions that were related to amino acid metabolism, biosynthesis of secondary metabolites, nucleotide biosynthesis, NAD+ kinase, carbohydrate, and energy metabolism, and formate C-acetyltransferase
Summary
Gallstone (45%) remains the leading cause of AP, followed by alcohol abuse (20%) [1]
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