Abstract
A series of Xantphos-based ligands containing various substituents in the diphenylphosphino groups were synthesized, and their effect on the product yield and ratio in the palladium-catalyzed arylation of ureas with nonactivated aryl halides was studied. The arylation of urea and phenylurea in the presence of Pd2(dba)3-CHCl3, 3,5-(CF3)2Xantphos, and Cs2CO3 in dioxane at 100°C gave the corresponding N,N'-diarylureas in 62-98% yield.
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