Abstract
BackgroundUrsolic acid (UA) is an important bioactive component in many traditional medicinal plants including pomegranate (Punica granatum L.) flower.MethodsThis study presents the HPLC analysis of UA contents of ten cultivars of pomegranate flower grown in Iran. The UA contents of fallen flowers of pomegranate were given in each cultivar.ResultsRemarkable quantities of UA were found in ten cultivars of Iranian pomegranate flower evaluated (21.736 to 15.119 mg/g). Lower quantities of UA were determined in pomegranate fallen flowers (16.763 to 5.754 mg/g).ConclusionUA values obtained from Iranian cultivars of pomegranate flowers are very significant when compared with other sources of UA. All of the analyzes suggested that the Iranian pomegranate flowers (including flowers on branches and fallen flowers) might be an excellent UA rich source.
Highlights
Ursolic acid (UA, 3β-hydroxy-12-urs-12-ene-28-oic acid) (Fig. 1) as an ursane-type pentacyclic triterpene, is a constituent of some medicinal plants [1]
This study evaluates the variation of UA content in ten cultivars of pomegranate flower grown in Iran, as determined by high performance liquid chromatography (HPLC) analysis
The optimized chromatographic conditions were subsequently applied for the analysis of UA content in ten different cultivars of pomegranate flower
Summary
Ursolic acid (UA, 3β-hydroxy-12-urs-12-ene-28-oic acid) (Fig. 1) as an ursane-type pentacyclic triterpene, is a constituent of some medicinal plants [1]. UA possesses considerable pharmacological effects including hepatoprotective [2, 3], immunomodulatory [4], antiinflammatory [5, 6], antidiabetic [7, 8], antitumor [9, 10], antiulcer [11] and anticancer activities [12, 13]. UA has attracted increasing attention due to its multifunctional anticancer activities [13, 14]. Ursolic acid (UA) is an important bioactive component in many traditional medicinal plants including pomegranate (Punica granatum L.) flower
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