Abstract
1. 1. Anaesthetized rats were given [ 3H]orotic acid either intraperitoneally or via a catheter into the hepatic artery with or without degradable starch microspheres. 2. 2. The radioactivity in the acid soluble and RNA fractions of five pieces of the left lateral liver lobes was determined. 3. 3. A variation of the distribution of the precursor into the different parts of the same liver lobe was shown. 4. 4. This variation was most pronounced (3000–17,000 cpm/μg in the acid soluble fraction) when the precursor was administered via the artery and without microspheres. 5. 5. The correlation between the radioactivity in the acid soluble and RNA fractions within each liver piece was 0.85, 0.90 and 0.75 in the three groups respectively. 6. 6. It is suggested that the variation of the distribution depends on circulatory differences within the liver.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
