Variation of hepatic enzymes with Vitamin B12 and D3 levels in cirrhotic patients

Hasnain Abbas Dharamshi ,Tufail Raza ,Farwa Fatima ,Amber Batool ,Kiran Fatima ,Ahmad Faraz ,Ahmed Siddiqui ,Syeda Sadia Fatima ,Mir Aftab Hussain Talpur ,Tahira Naqvi ,Syed Sibte Raza Abidi

doi:10.3823/1653

Hasnain Abbas Dharamshi , Tufail Raza + Show 9 more

Open Access

https://doi.org/10.3823/1653

Copy DOI

Abstract

OBJECTIVE: To determine variation of hepatic enzymes Vitamin B12 and D3 levels in cirrhotic patients. DESIGN: Cross sectional study. SETTING: Cirrhotic patients in Abbasi Shaheed Hospital. PARTICIPANTS: 250 patients in Abbasi Shaheed Hospital with diagnosis of cirrhosis including 141 males and 109 females. VARIABLE PARAMETERS: They include mean ALT, GGT, Alkaline phosphatase levels along with Vitamin B12 and D3 levels in blood. RESULTS: Vitamin B12 levels were 1249.59±487.01pg/ml and 1422.28±627.75pg/ml in males and females respectively while Vitamin D3 levels were found to be 17.15±10.45 nmol/L in males and 14.80±14.24 nmol/L in females. Vitamin B12 levels were found to be positively correlated with the elevation of ALT and were negatively correlated with elevation of ALT, GGT and Alkaline Phosphatase. The ALT levels were 50.0±21.88 in males and 14.80±14.24 in females, Alkaline phosphatase to be 311.46±107.98 in males while female Alkaline phosphatase were 346.47±101.60. GGT levels to be 41.70±10.62 in males and 45.01±13.74 in females. CONCLUSION: Cirrhotic patients suffering from severe hepatocellular damage have their elevated levels of Vitamin B12 and depressed Vitamin D3 levels in plasma accompanied by a positive association with elevated ALT and GGT plasma levels

Highlights

Vitamin D maintains calcium homeostasis by interacting with the vitamin D receptor (VDR) in osteoblasts
The P Value of F statistic is
The p value of ALT, GGT and Alkaline Phosphatase is less than alpha which means that their coefficients are statistically significantly different from 0

Summary

Introduction

Vitamin D maintains calcium homeostasis by interacting with the VDR in osteoblasts. It induces the expression of plasma membrane protein receptor activator of NF-κB ligand (RANKL). 25(OH), D is used to measure the level of Vitamin D in the circulation. Deficiency of Vitamin D is associated with the increased risk of colon, breast and prostate cancer [4], cardiovascular infections [5, 6] and autoimmune diseases. [8, 9] There is a strong association of vitamin D3 levels and the presence of liver disease. Vitamin D is not converted into its active form, resulting in hypovitaminosis. Research showed that almost 2/3rd of the patients with chronic viral hepatitis had abnormal levels of vitamin D while 1/3rd had some deficiency

Results

Discussion

Conclusion