Abstract
Fetal mouse tissues on gestational days 14, 16 and 19 were incubated with 14C-corticosterone (B) and 3H-11-dehydrocorticosterone (A), and the steroids were separated chromatograhically to determine the ratio reduction/dehydrogenation. In placenta the ratio remained high, >6, throughout this period, while it rose from 0.06 to 0.6 in brain and from 0.1 to 0.5 in gut. In liver, the ratio increased from 0.29 on day 14 to 3.54 on day 16; in lung it rose from 0.29 on day 16 to 6.7 on day 19. Injection of mothers 16 hr earlier with dexamethasone increased the ratio in lung and placenta on day 16 but not earlier. The unchanged 3H-corticosterone recovered from fetal tissues 15 min after injection into mothers was <3% on day 14 but increased manyfold in all tissues by day 19. It is concluded that corticosteroids are regulated in fetal mouse tissues by the interconversion of the hormone and its 11-dehydro metabolite, and that the pattern varies in different tissues and changes with gestational age.
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