Abstract
AbstractKRTAP8-1was the initial high-glycine-tyrosine keratin-associated protein gene recognized in sheep, but little is known about the functional influence of this gene. The current study used polymerase chain reaction-single stranded conformational polymorphism analysis to genotypeKRTAP8-1in 391 Southdown × Merino-cross sheep from six sire-lines. Five previously described variants (namedAtoE) ofKRTAP8-1were identified with frequencies of 67.0, 14.2, 7.0, 10.7 and 1.0%, respectively. Of the four variants (A,B,CandD) that occurred at a frequency greater than 5%, the presence ofCwas found to be associated with a reduction in mean fibre curvature (MFC) and the presence ofDwas associated with an increase in mean staple strength (MSS), whereas the presence ofAhad a trend of association with reduced MSS. Associations were not identified with other wool traits. These results suggest that variation inKRTAP8-1affects MSS and MFC, and thatKRTAP8-1has the potential to be used as a genetic marker for improving these traits.
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