Variation in Lipid Profile during Different Interval of Gestation Period

Abstract

Just after conception, there is a highly increased demand of energy and carbon for various metabolic or anabolic pathways rather to furnish the molecular requirement of foetus and mother as well. To achieve the target, there are lot of changes that occur at every level belonging to anatomy, physiology and biochemistry. An inclined physiological factor reflects in the biochemical parameter of the subject. Lipid profile is one of them. The lipid profile is major element and prerequisite to atherosclerosis and may cause unconsciousness. To save mankind from this problem, it is planned to observe and analyse the changes in the lipid profile during various trimesters of gestation period. For this research work, 80 subjects of 30-40 age group were selected against 50 subjects of the same age group as a control. Overnight fasting at least 10 h is allowed before taking the sample. Total cholesterol, HDL, LDL, VLDL, triglyceride were estimated by the enzymatic colorimetric kit method in Divya Jyoti Institute of Medical Sciences and Research, Niwari Road, Modinagar, Ghaziabad, UP, India. Total cholesterol, LDL, VLDL, triglyceride increased while HDL decreased from the first to third trimester in pregnant women. This may change the lipid profile, associated with length of gestation period are observed disturbed in each trimester and this explains that variation in the lipid profile is somehow associated with the gestation period. In brief, there is a chance of elevation for coronary heart disease and other ailments concerned with mother/foetal health. This is suggestive that the routine lipid profile analysis is necessary to prevent the risk during the antenatal period. Studies are required further to observe whether pregnancy affects their life from coronary vascular disease in the later stage or not.