Abstract
BackgroundAtopic dermatitis (AD) is believed to result from complex interactions between genetic and environmental factors. A main feature of AD as well as other allergic disorders is serum and tissue eosinophilia. Human eosinophils contain high amounts of cationic granule proteins, including eosinophil cationic protein (ECP), eosinophil-derived neurotoxin (EDN), eosinophil peroxidase (EPO) and major basic protein (MBP). Recently, variation in genes encoding eosinophil granule proteins has been suggested to play a role in the pathogenesis of allergic disorders. We therefore genotyped selected single nucleotide polymorphisms within the ECP, EDN, EPO and MBP genes in a cohort of 361 German AD patients and 325 healthy controls.ResultsGenotype and allele frequencies did not differ between patients and controls for all polymorphisms investigated in this study. Haplotype analysis did not reveal any additional information.ConclusionWe did not find evidence to support an influence of variation in genes encoding eosinophil granule proteins for AD pathogenesis in this German cohort.
Highlights
Atopic dermatitis (AD) is believed to result from complex interactions between genetic and environmental factors
We genotyped a total of nine single nucleotide polymorphisms (SNPs) in four genes encoding eosinophil granule proteins. rs10132319 in intron 1 of the eosinophil-derived neurotoxin (EDN) gene turned out to be monomorphic in our cohort and was excluded from further analysis
None of the polymorphisms investigated here showed an association with AD in our cohort
Summary
Atopic dermatitis (AD) is believed to result from complex interactions between genetic and environmental factors. A main feature of AD as well as other allergic disorders is serum and tissue eosinophilia. Variation in genes encoding eosinophil granule proteins has been suggested to play a role in the pathogenesis of allergic disorders. Atopic dermatitis (AD) is a chronic inflammatory skin disease believed to arise from complex interactions between genetic and environmental factors [1]. As a main feature of allergic disorders, AD is often accompanied by eosinophilia [2]. Human eosinophils contain high amounts of cationic granule proteins, including eosinophil cationic protein (ECP), eosinophil-derived neurotoxin (EDN), eosinophil peroxidase (EPO) and major basic protein (MBP). Serum and urine concentrations of eosinophil proteins are indirect measures of inflammatory activity in AD. Measurement of ECP levels in serum is a frequently used tool in monitoring AD activity [4,6]
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