Abstract
Objectives: Blood cholesterol concentration is positively associated with atherosclerosis and cardiovascular disease risk. Cholesterol absorption efficiency displays a high inter-individual variability that is assumed to be due to both dietary and genetic factors. Several polymorphisms have been identified but existing studies have so far focused on single SNPs that only explained a minor fraction of the variability of such a complex phenotype. This study thus aimed to identify a combination of SNPs that could explain a significant part of the variability in cholesterol absorption efficiency.
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