Abstract
Murraya koenigii (MK) leaf being a rich source of bioactive secondary metabolites has received inordinate attention in drug development research. Formation of secondary plant metabolite(s) in medicinal plants depends on several factors and in this study the cause of variation in bioavailability and content of a vital bioactive phytochemical, mahanine in the MK leaves from different geographical locations of varying soil properties and weather parameters was determined. Accordingly, MK leaves and soil samples around the plant base in quintuplicate from each site across five states of India at similar time point were collected. Mahanine content was determined and compared among samples from different regions. The quantitative analysis data comprised that MK-leaves of southern part of India contains highest amount of mahanine, which is 16.9 times higher than that of MK-leaves of north-eastern part of India (which measured as the lowest). The results suggested that pH, conductivity and bacterial populations of the soil samples were positively correlated with mahanine content in the MK-leaves. For examples, the average soil pH of the southern India sites was in basic range (8.8 ± 0.6); whereas that of the north-east India sites was in slightly acidic ranges (6.1 ± 0.5) and mean soil conductivity value for the north east India soils was 78.3 ± 16.3 µS/cm against mean value of 432.4 ± 204.5 µs/cm for south India soils. In conclusion, this study proclaims that higher level of bioactive phytochemical, mahanine in MK leaves depending upon geographical location, weather suitability and soil’s physiochemical and microbial parameters of its cultivation sites.
Highlights
Murraya koenigii (MK) leaf being a rich source of bioactive secondary metabolites has received inordinate attention in drug development research
The direct role of secondary metabolites on plant growth and maturity is still not clear and needs further thorough research[11,12], the contribution of that secondary plant metabolite (SPM) towards pharmaceutical drug development has been well recognized for centuries[13]
The primary objectives of this study were to (i) determine the variation of mahanine in MK leaves collected at single time point from different geographical locations of varying soil and weather parameters and (ii) possible association of soil, microbes and weather parameters with the mahanine biosynthesis in MK leaves of diverse locations
Summary
Murraya koenigii (MK) leaf being a rich source of bioactive secondary metabolites has received inordinate attention in drug development research. Formation of secondary plant metabolite(s) in medicinal plants depends on several factors and in this study the cause of variation in bioavailability and content of a vital bioactive phytochemical, mahanine in the MK leaves from different geographical locations of varying soil properties and weather parameters was determined. In one of our recent study[2], which involved isolation procedure of mahanine from MK leaves, we witnessed varied range of biosynthesis (of mahanine) depending upon the place, time of collection of the leaf samples as well as weather conditions of the plant sample collection sites. The primary objectives of this study were to (i) determine the variation of mahanine in MK leaves collected at single time point from different geographical locations of varying soil and weather parameters and (ii) possible association of soil, microbes and weather parameters with the mahanine biosynthesis in MK leaves of diverse locations
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