Variation and clinical significance of serum cardiac troponin I and interleukin-6 in patients with acute organophosphorus pesticide poisoning

Abstract

Objective To explore the variation and clinical significance of serum cardiac troponin I (cTnI) and interleukin-6 (IL-6) in patients with acute organophosphorus pesticide poisoning (AOPP).Methods The serum cTnI and IL-6 levels in 97 patients with AOPP(AOPP group) and 40 healthy subjects (control group) were tested by double antibody sandwich enzyme linked immunosorbent assay and compared between two groups.Results The serum cTnI and IL-6 levels in AOPP group on admission,admission 1,3 d were respectively (2.51 ± 0.80),(2.11 ± 0.67 ),( 1.58 ± 0.50) μ g/L and ( 154.82 ± 49.15 ),( 139.33 ± 44.23),(108.37 ± 34.40) ng/L,which were higher than those in control group [(0.02 ± 0.01 )μ g/L,(82.61 ± 26.23) ng/L] (P ＜ 0.05).The serum cTnI and IL-6 levels increased with increasing degrees of poisoning.The different degrees of poisoning was positively correlated with the serum cTnI and IL-6 levels (r =0.642,0.517,P ＜ 0.05).Conclusions The degrees of poisoning,myocardial damage and inflammatory reaction of AOPP patients are closely related to the serum cTnI and IL-6 levels.The dynamic observation of the serum cTnI and IL-6 levels has an important significance for the judging the severity of myocardial damage and inflammatory reaction of AOPP patients. Key words: Troponin I; Interleukin-6; Acute organophosphorus pesticide poisoning