VARIASI EKSTRAK ETANOL BIJI ALPUKAT (Persea americana Mill.) PADA GRANUL EFFERVECSENT SEBAGAI ANTIDIABETES

Abstract

This study aims to product the preparation effevecsent granule using variation of ethanol extract avocado seed ( Persea americana Mill . ) as antidiabetic using granulation method. This study was conducted using two formulas using variation of ethanol extract avocado seed ( Persea americana Mill . ) 1% and 10%, PVP K30 4%, Sodium cyclamate 0.1%, citric acid 0.2965 gram, tartric acid 0.5931 gram and sodium bicarbonate 1.0083 gram. The test results of evaluation preparation effevecsent granule using variation of ethanol extract avocado seed ( Persea americana Mill . ) showing that formulas 2 (two) is the best the result farmaceutic evaluation obtained with value Densitas Bulk = 2.82, Incompressible Density = 0.353, Carr’s Indeks = 17.12, Silent Angle = 19.79 0 , Flow Time = 0.7, Time of Stopping Foam = 1.15. The test results of antidiabetic at in vivo formulas 2 (two) preparation effevecsent granule of ethanol extract avocado seed ( Persea americana Mill . ) using male mice ( Mus musculus ) with weight 176.5 mg, Initial Glucose Level = 87.5, Initial Glucose Induction = 249.5 obtained time of giving theraphy of formula at first day = 248.5, second day = 133, five day = 109 and seven day = 75.5, so preparation effevecsent granule of ethanol extract avocado seed ( Persea americana Mill . ) effective as antidiabetic.