Abstract
We conducted a case-control matched study to investigate the role of IL-16 gene polymorphisms, rs4072111, rs1131445, rs4778889 and rs11556218, in the risk of gastric cancer in a Chinese population, also performing subgroup analysis by subsites. To test the hypothesis of involvement, we analyzed the four SNPs of IL16 in 347 cancer patients and 368 controls. Demographic data and other information were collected using a newly designed questionnaire. Genotyping of IL16 (rs4072111, rs1131445, rs4778889 and rs11556218) was performed in a 384-well plate format on the MassARRAY® platform. In our study, we found the gastric cancer patients were more likely to be male and have a family history of cancer (P < 0.05). We found the rs4778889 CC and rs11556218 GG genotype was significantly associated with 1.97 and 1.84-fold increased risk of non-cardia gastric cancer, while we did not find significant association between the four IL-16 SNPs and cardia gastric cancer. In conclusion, our study indicated that IL-16 rs4778889 CC and rs11556218 GG genotypes are associated with an increased risk of non-cardia gastric cancer in a Chinese population. Our results offer insights into the influence of IL-16 on development of gastric cancer.
Highlights
Worldwide, gastric cancer is the second leading cause of death from cancer, with an estimated one million new cases in 2008 (988 000 cases), accounting for 8% of all cancerrelated death worldwide
There was only one study reported the association between IL-16 polymorphisms and risk of gastric cancer (Gao et al, 2009a), and this case-control study indicated that rs11556218T/G and rs4072111C/Tpolymorphisms of the IL-16 gene was significantly associated with the susceptibility to gastric cancer patients
The main finding in our study was that IL-16 rs4778889 CC and rs11556218 GG genotypes were associated with an increased risk of developing non-cardia gastric cancer, while IL-16 rs4072111C>T and rs1131445T>C polymorphisms had no association
Summary
Gastric cancer is the second leading cause of death from cancer, with an estimated one million new cases in 2008 (988 000 cases), accounting for 8% of all cancerrelated death worldwide. The interleukin (IL) represent a diverse constellation of cytokines which regulate the function of immune system in human They are produced predominantly by T cells, monocytes, macrophages, and endothelial cells. IL-16 is precursor protein consisting of 631 amino acids, which is cleaved by caspase-3 to form the active C-terminal domain containing 121 amino acids (Baier et al, 1997; Drwinga et al, 1993; Zhang et al, 1998), and can promote the secretion of tumor-associated inflammatory cytokines by monocytes, such as IL-1b, IL-6 and IL-15 (Mathy et al, 2000), and play an important role in the carcinogensis of human cancers (Schneider et al, 2000; Chung and Chang, 2003; Kai et al, 2005; Shanmugham et al, 2006). Higher serum levels of IL-16 have been associated with advanced stages of cancer and a worse patient outcome depending on the type of tumor
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