VARIANTS OF ADRENAL MYELOLIPOMAS AND RARE CONCOMITANT DISEASES

Abstract

Background: Adrenal myelolipoma is a rare tumor, etiology and pathogenesis of which aren’t completely defined. Intensified investigation of the tumor structural components in concomitant adrenal lesions and associated diseases enables more comprehensive discovery of its histogenesis features and more adequate assessment of the cause of different correlations between adipose and hemopoietic components of the tumor. Aim: Specification of the structural features of different variants of adrenal myelomas based on the analysis of the outcome of this tumor morphologic study including possible influence of associated diseases. Materials and methods: A total of 16 observations of adrenal myelolipomas are presented in the study including 11 “pure” tumors, 2 mixed (adenomas/myelolipomas), and 3 concurrent ones (adenoma and myelolipoma). Results: Correlation between hemopoietic elements and adipose tissue varies in both “pure” myelolipoma and combined adrenal tumor. Cavernous spleen hemangioma, accompanied by destruction of hemopoietic cells, gastrointestinal stromal tumor, and Hailey-Hailey disease, all based on genetic mutations, are rare concomitant diseases in adrenal myelolipoma. Conclusion: Myelolipoma tumorogenesis depends not only on concomitant pathology in adrenal gland but also on myelolipoma association with diseases stimulating histogenesis of both fatty cells and hemopoietic elements.