Abstract
Rabies is one among the most dangerous diseases reported to have a wider range of incubation period and clinical signs. The disease is manifested as furious or paralytic forms in dogs. The combined effects of virulence and pathogenicity of the virus along with host immune factors are the main variables leading to variation in manifestation of the disease. This paper reports the finding of a study conducted in rabies positive canine cases to correlate the role of pathophysiological factors in clinical manifestation of rabies. A total of 23 rabies positive cases were studied and their anamnesis collected. Male dogs less than 5 years of age constituted major proportion of rabies positive cases. Site of bite was observed as a critical factor in disease manifestation. Anti-rabies prophylactic vaccination had significant effect as none of the vaccinated animals developed furious form of rabies. But paralytic form was found in irregularly vaccinated dogs, probably due to effect of vaccination imparting partial immune response in these animals.
Highlights
Rabies is one among the most dangerous diseases reported to have a wider range of incubation period and clinical signs
In a comparative study of two forms of rabies conducted by Mitrabhakdi et al (2005), where limbic signs dominated in the furious form, paralysis of lower motor neuron was prominent in the paralytic form of rabies
In a study conducted by Mitrabhakdi et al (2005), 65 per cent of rabies cases with the clinical manifestation of paralytic form had bite marks on the hind limb or distal extremities of the body, while more than 65 per cent of furious form rabies cases were encountered in patients bitten on their face or fore limb by a rabid animal
Summary
Rabies is one among the most dangerous diseases reported to have a wider range of incubation period and clinical signs. Single dog at its infectious period have been reported to transmit the disease, which was manifested in different forms in different animals (Hemachudha et al, 2002). In the present study the animal owners were provided with the preformed questionnaire to collect the details on preexposure anti rabies vaccination, bite history, clinical signs, duration of incubation and duration of illness exhibited by the rabid animal.
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