VARIANTS AND PERSPECTIVES OF DRUG REPURPOSING FOR CANCER TREATMENT

A V Savinkova,E A Lesovaya,E S Lylova,O A Vlasova,T I Fetisov,M G Yakubovskaya,K A Kuzin,E M Zhidkova,G A Belitskiy,L R Tilova,K I Kirsanov,V P Maximova,M D Lavrova,A Yu Portyannikova,A V Kholodova

doi:10.21294/1814-4861-2018-17-3-77-87

Abstract

Recently many new approaches for repurposing or repositioning of the clinically used drugs have been developed. Drug repurposing allows not only to use known schemes for the synthesis of biologically active compounds, but also to avoid multiple studies that are necessary for drug approval process – analysis of pharmacokinetics, carcinogenicity, acute and chronic toxicity, including cardiotoxicity, nephrotoxicity, allergenicity etc. It makes possible to reduce the number of experimental studies as well as costs of investigations. In cancer research drug repurposing includes screening for medicines used nowadays for the treatment of patients with non-cancer diseases which possess anticancer activity or able to enhance the effects of the standard anticancer chemotherapy, and search for new applications of known anticancer drugs for the treatment of different cancer types. Scientific rationale for the search of the compounds with potential anticancer properties among drugs with different applications is based on the multiple cross-talks of signaling pathways, which can inhibit cell proliferation. Modern advances in genomics, proteomics and bioinformatics, development of permanently improving databases of drug molecular effects and high throughput analytical systems allow researchers to analyze simultaneously a large bulk of existing drugs and specific molecular targets. This review describes the main approaches and resources currently used for the drug repurposing, as well as a number of examples.

Highlights

Drug repurposing allows to use known schemes for the synthesis of biologically active compounds, and to avoid multiple studies that are necessary for drug approval process – analysis of pharmacokinetics, carcinogenicity, acute and chronic toxicity, including cardiotoxicity, nephrotoxicity, allergenicity etc
In cancer research drug repurposing includes screening for medicines used nowadays for the treatment of patients with non-cancer diseases which possess anticancer activity or able to enhance the effects of the standard anticancer chemotherapy, and search for new applications of known anticancer drugs for the treatment of different cancer types
Scientific rationale for the search of the compounds with potential anticancer properties among drugs with different applications is based on the multiple cross-talks of signaling pathways, which can inhibit cell proliferation

Summary

Introduction

Для цитирования: Савинкова А.В., Жидкова Е.М., Тилова Л.Р., Лаврова М.Д., Лылова Е.С., Кузин К.А., Портянникова А.Ю., Максимова В.П., Холодова А.В., Власова О.А., Фетисов Т.И., Кирсанов К.И., Белицкий Г.А., Якубовская М.Г., Лесовая Е.А. Варианты и перспективы перепрофилирования лекарственных препаратов для использования в терапии онкологических заболеваний. For citation: Savinkova A.V., Zhidkova E.M., Tilova L.R., Lavrova M.D., Lylova E.S., Kuzin K.A., Portyannikova A.Y., Maximova V.P., Kholodova A.V., Vlasova O.A., Fetisov T.I., Kirsanov K.I., Belitskiy G.A., Yakubovskaya M.G., Lesovaya E.A. Variants and perspectives of drug repurposing for cancer treatment.

Results

Conclusion