Variant of PAI-2 gene is associated with coronary artery disease and recurrent coronary event risk in Chinese Han population

Xia Li,Bang-Dang Chen,Jun-Yi Luo,Lei Zhang,Yi-Ning Yang,Fen Liu,Yi-Tong Ma,Xiang Xie

doi:10.1186/s12944-015-0150-y

Abstract

BackgroundPlasminogen activator inhibitor −2 (PAI-2) is an important molecular that plays a crucial role in vascular homeostasis and constitutes a critical response mechanism to cardiovascular injury, such as atherosclerosis, coronary artery disease (CAD).MethodsThe aim of the current study was to explore the association between the variants in PAI-2 gene and CAD and its prognoses. The three variants (rs8093048, rs9946657, rs9320032) of the PAI-2 gene were detected in 407 patients with CAD and 518 control subjects. All patients with CAD underwent one-year follow-up for major adverse cardiac events (MACE).ResultsThe frequencies of the TT genotype and T allele of rs8093048 was significantly higher in CAD patients than that in control subjects (7.6 % vs.3.5 %, P = 0.003, 28.1 % vs.21.7 %, P < 0.001, respectively). Multifactor logistic regression analysis showed that the TT genotype of rs8093048 was a risk factor for CAD (OR = 1.455, 95 % CI: 1.069-1.980, P = 0.017). In addition, the follow-up data showed that CAD patients with rs8093048 TT genotype had significantly higher rate of refractory angina and MACE than those with CC or CT genotype (P = 0.032, P = 0.009, respectively). Cox regression analysis showed that rs8093048 TT genotype was the risk factor for the MACE (Hazard ratio = 5.672, 95 % CI = 1.992-16.152, P = 0.001).ConclusionWe firstly found that the variant of PAI-2 gene was associated with CAD and recurrent coronary event risk in Chinese Han population, in Xinjiang.

Highlights

Plasminogen activator inhibitor −2 (PAI-2) is an important molecular that plays a crucial role in vascular homeostasis and constitutes a critical response mechanism to cardiovascular injury, such as atherosclerosis, coronary artery disease (CAD)
The PAI-2 gene rs8093048 TT genotype and T allele distribution was significantly higher in CAD patients than that in control subjects (7.6 % versus 3.5 %, P = 0.003, 28.1 % versus 21.7 %, P < 0.001, respectively)
For rs9946657 and rs9320032, we did not found any significant difference in the genotypic and allelic distribution of PAI-2 gene between CAD patients and controls

Summary

Introduction

Plasminogen activator inhibitor −2 (PAI-2) is an important molecular that plays a crucial role in vascular homeostasis and constitutes a critical response mechanism to cardiovascular injury, such as atherosclerosis, coronary artery disease (CAD). The plasminogen activator (PA) system plays a key role in vascular homeostasis and constitutes a critical response mechanism to cardiovascular injury, such as atherosclerosis, coronary artery disease (CAD), myocardial infarction (MI) and restenosis [1]. Nur Buyru et al investigated 45 myocardial infarction patients and 20 control subjects, they found that the variant at the 413 position (AA genotype) of PAI-2 gene was associated with an increased risk of MI [12]. Zhao et al genotyped 57 patients with CAD and 62 controls, it indicated that PAI-2 gene Ser/Cys413 15588 G/C polymorphism was associated with CAD and the C allele was a risk factor for CAD [14]. We built a prospective cohort study of the CAD patients to analyze the major adverse cardiac events (MACE) among different genotypes of PAI-2 gene for a mean period of one-year follow-up

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Results