Abstract
Background: Mutations in the vacuolar protein sorting 35 ortholog (VPS35) gene have recently been reported as a new cause of late-onset, autosomal dominant familial Parkinson's disease (PD). AspD620Asn (D620N), has been identified to cause PD in multiple individuals and families worldwide. VPS35 encoded a core component of the retromer complex, however, the exact molecular mechanism by which VPS35 mutations induce progressive neurodegeneration in PD are not fully elucidated.
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