Variables associated with mortality in patients with atrial fibrillation and ischaemic heart disease in Spain

Abstract

Abstract Funding Acknowledgements None. Introduction The prevalence of atrial fibrillation (AF) and ischaemic heart disease (IHD) increases with age, conditioning a complex and relatively frequent scenario in clinical practice. Our objective was to know the variables associated with prognosis in a cohort of patients with AF and IHD in our country after a year of follow-up. Methods An observational, prospective and multicentre study that included patients with AF and IHD in Spain. Baseline, clinical, laboratory and echocardiographic characteristics were assessed, as well as the clinical management and the choice of antithrombotic treatment. We studied long-term mortality. Results 290 patients were included (mean age 77.7±9.7 years, 28% women). 84% of the patients were hypertensive, 42% diabetic, 69.7% dyslipidemic. The average comorbidity, characterized by the Charlson index, was 2.3±2. The average score on the CHADSVASC and HASBLED scales was 4.28±1.62 and 2.94±1, respectively. The clinical presentation of ischaemic heart disease was NSTEMI (45%), STEMI (22%) and stable angina (33%). 65.6% of patients underwent revascularisation, mostly percutaneously (92%). 42% of patients were discharged with triple therapy (double antiplatelet + anticoagulation), 30.1% with double therapy (antiplatelet + anticoagulation). After an average follow-up of 325±5.7 days, 35 patients (12%) died. The variables independently associated (multivariate analysis) with mortality during follow-up are shown in the Table (creatinine, leukocyte count, troponin elevation, number of diseased vessels, ventricular function, and comorbidity were mortality predictors in our study). Conclusions The presence of a series of simple variables identifies patients with AF and IHD as having a greater risk of mortality during follow-up.Variables independentily associated AF