Abstract
Purpose: Platelet-rich plasma (PRP) injections are receiving increasing interest as a treatment for knee osteoarthritis (OA). PRP is prepared by centrifugation of whole blood, resulting in greater concentrations of platelets and associated growth factors than whole blood. Despite encouraging preclinical results and clinical reports of improvements in pain, there remain questions regarding the efficacy of PRP for knee OA due to methodological concerns and heterogeneity between studies. The lack of objective tools for assessing interventions is a critical barrier towards evaluating therapies for knee OA.
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