Abstract

Translation in vivo of colicin A messenger RNA was studied. Accumulation of nascent chains of discrete sizes was observed, providing evidence that the rate of chain elongation during colicin A biosynthesis was not uniform. This discontinuous translation was independent of induction of colicin A by mitomycin C and of the bacterial host for colicin A plasmid. A variable rate of chain elongation in vivo was also demonstrated for colicins E2 and E3. The possible roles of codon usage and mRNA secondary structure are discussed.

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