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Abstract
BackgroundFreezing of gait is a common and debilitating symptom affecting many patients with advanced Parkinson’s disease. Although the pathophysiology of freezing of gait is not fully understood, a number of observations regarding the pattern of gait in patients with this symptom have been made. Increased ‘Stride Time Variability’ has been one of the most robust of these features. In this study we sought to identify whether patients with freezing of gait demonstrated similar fluctuations in their stepping rhythm whilst performing a seated virtual reality gait task that has recently been used to demonstrate the neural correlate of the freezing phenomenon.MethodsSeventeen patients with freezing and eleven non-freezers performed the virtual reality task twice, once whilst ‘On’ their regular Parkinsonian medication and once in their practically defined ‘Off’ state.ResultsAll patients displayed greater step time variability during their ‘Off’ state assessment compared to when medicated. Additionally, in the ‘Off’ state, patients with freezing of gait had greater step time variability compared to non-freezers. The five steps leading up to a freezing episode in the virtual reality environment showed a significant increase in step time variability although the final three steps preceding the freeze were not characterized by a progressive shortening of latency.ConclusionsThe results of this study suggest that characteristic features of gait disturbance observed in patients with freezing of gait can also be demonstrated with a virtual reality paradigm. These findings suggest that virtual reality may offer the potential to further explore the freezing phenomenon in Parkinson’s disease.
Highlights
Freezing of gait (FOG) is a debilitating symptom that affects over 50% of patients with advanced Parkinson’s disease (PD) [1]
Previous studies have identified that those PD patients who suffer from FOG display specific changes in gait, most notably having a generally increased stride time variability [6,7,8]
The stride time variability is partially ameliorated by dopaminergic medication in PD with increased variability being reported in the ‘Off’ state [7,8,9,10]
Summary
Freezing of gait (FOG) is a debilitating symptom that affects over 50% of patients with advanced Parkinson’s disease (PD) [1]. This paroxysmal phenomenon is defined by the absence or marked reduction in forward progression of the feet despite the intention to walk [2]. Previous studies have identified that those PD patients who suffer from FOG display specific changes in gait, most notably having a generally increased stride time variability [6,7,8]. Freezing of gait is a common and debilitating symptom affecting many patients with advanced Parkinson’s disease. In this study we sought to identify whether patients with freezing of gait demonstrated similar fluctuations in their stepping rhythm whilst performing a seated virtual reality gait task that has recently been used to demonstrate the neural correlate of the freezing phenomenon
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