Abstract

Normal Wechsler Adult Intelligence Scale (WAIS)-IV performance relative to average normative scores alone can be an oversimplification as this fails to recognize disparate subtest heterogeneity that occurs with increasing age. The purpose of the present study is to characterize the patterns of raw score change and associated variability on WAIS-IV subtests across age groupings. Raw WAIS-IV subtest means and standard deviations for each age group were tabulated from the WAIS-IV normative manual along with the coefficient of variation (CV), a measure of score dispersion calculated by dividing the standard deviation by the mean and multiplying by 100. The CV further informs the magnitude of variability represented by each standard deviation. Raw mean scores predictably decreased across age groups. Increased variability was noted in Perceptual Reasoning and Processing Speed Index subtests, as Block Design, Matrix Reasoning, Picture Completion, Symbol Search, and Coding had CV percentage increases ranging from 56% to 98%. In contrast, Working Memory and Verbal Comprehension subtests were more homogeneous with Digit Span, Comprehension, Information, and Similarities percentage of the mean increases ranging from 32% to 43%. Little change in the CV was noted on Cancellation, Arithmetic, Letter/Number Sequencing, Figure Weights, Visual Puzzles, and Vocabulary subtests (<14%). A thorough understanding of age-related subtest variability will help to identify test limitations as well as further our understanding of cognitive domains which remain relatively steady versus those which steadily decline.

Highlights

  • In the absence of effective treatments for Alzheimer’s disease (AD), new therapeutical approaches that may assist in preventing and/or delaying the onset of AD appear essential

  • Nowadays, growing neuroimaging evidence in cognitively normal individuals points to potential links between lifestyle factors and AD neuropathological expression (Figure 4B), which suggests that the effects of lifestyle might be exerted via both compensatory and neuroprotective mechanisms

  • While studies in AD patients point to lifestyle-related compensatory mechanisms, new evidence in cognitively normal elders with AD neuroimaging biomarkers and preclinical AD subjects suggests that lifestyle factors may directly impact the development of AD neuropathology

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Summary

Introduction

In the absence of effective treatments for Alzheimer’s disease (AD), new therapeutical approaches that may assist in preventing and/or delaying the onset of AD appear essential. These studies included: (i) samples of cognitively normal older adults with neuroimaging biomarker information (and CSF markers in some of them); or (ii) older adults considered to be at higher risk for AD (that may in part represent the preclinical AD stage), such as older adults showing pathological levels of Aβ deposition or carrying the ε4 allele of the Apolipoprotein (APOE) gene (the highest known genetic risk factor for sporadic AD) While some of these investigations are in agreement with the notion that lifestyle factors may have a modulatory effect on the brain, other studies provide new clues on the neural mechanisms underlying the effects of lifestyle factors on the brain and on the potential mechanisms underlying cognitive and brain reserve. Direct effects of lifestyle in key regions such as the hippocampus and the temporal lobe have found support in several cross-sectional studies

Discussion
Summary and Perspectives

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