Abstract
G A A b st ra ct s in human esophageal epithelium as detected by PGP9.5 was absent.Epithelial ASIC3 was identified in all mucosal biopsies (14 controls, 18 non-erosive reflux disease, 4 erosive esophagitis). ASIC3 could be classified based on distribution and characteristic sub-cellular morphology into 4 groups; basal layer (stratum basale), stratum spinosum perinuclear, stratum spinosum membrane-bound, and superficial luminal layer staining. Patients with higher VAS symptom scores had greater expression of all 4 ASIC3 features studied (p= 0.018) with strongest associations between acid complaints and sleep disturbance (p=0.002). Conclusions: Presence of specific epithelial ASIC3 morphological features in esophageal epithelium was associated with increase in severity of common GERD symptoms.
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