Variability in the clinical distributions of Candida species and the emergence of azole-resistant non-Candida albicans species in public hospitals in the Midwest region of Brazil.

Karine Mattos,Marilene Rodrigues Chang,Adriana Almeida Araujo,Pedro Fernando Diniz,Luiza Inahê Marques,Kelly Mari Pires De Oliveira,Luana Carbonera Rodrigues

doi:10.1590/0037-8682-0163-2017

Abstract

Incidence and antifungal susceptibility of Candida spp. from two teaching public hospitals are described. The minimum inhibitory concentrations of fluconazole, voriconazole, itraconazole, and amphotericin B were determined using Clinical Laboratory Standard Institute broth microdilution and genomic differentiation using PCR. Of 221 Candida isolates, 50.2% were obtained from intensive care unit patients; 71.5% were recovered from urine and 9.1% from bloodstream samples. Candida parapsilosis sensu stricto was the most common candidemia agent. We observed variations in Candida species distribution in hospitals in the same geographic region and documented the emergence of non-C. albicans species resistant to azoles.

Highlights

Incidence and antifungal susceptibility of Candida spp. from two teaching public hospitals are described
Of 221 Candida isolates, 50.2% were obtained from intensive care unit patients; 71.5% were recovered from urine and 9.1% from bloodstream samples
This study investigated the incidence of Candida isolates and their antifungal susceptibility

Summary

Introduction

Abstract Introduction: Incidence and antifungal susceptibility of Candida spp. from two teaching public hospitals are described. Candida spp. are microorganisms that can cause infections ranging from superficial to systemic infections and are considered the main agents of fungal infections in hospitalized patients. This study investigated the incidence of Candida isolates and their antifungal susceptibility. This study included Candida spp. isolates obtained from different clinical specimens.

Results

Conclusion