Abstract
RESULTS: Tumor was distinguishable from normal tissue using both SPY and Pearl systems, with both platforms being able to detect tumor as small as 0.5 mg. Serial surgical resections demonstrated that real-time fluorescence can differentiate subclinical segments of disease. Pathologic examination of samples using histology, Odyssey (LI-COR), and immunohistochemistry confirmed that the bioconjugates were specific for tumor cells and were able to accurately distinguish these malignant areas from normal tissue.
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