Vancomycin-Loaded Porphyrinic MOF Nanoparticles for Killing Pathogenic Bacteria

Abstract

The synthesis of functional antibacterial nanoplatforms for killing pathogenic bacteria is urgent. Among them, combining traditional antibiotics with antimicrobial photodynamic therapy (PDT) is an attractive means. Here, we synthesized a multimodal antibacterial nanoplatform (denoted as Van/PCN) based on PCN-224 and vancomycin (Van). PCN-224 is a kind of photosensitizer-based nanoscale metal organic framework (pMOF), which not only possessed large surface area and many binding sites for loading Van but also had the ability to produce ROS under visible light irradiation. Van/PCN killed bacteria by Van and ROS, achieving a synergistic antibacterial effect. Since Gram-positive bacteria are sensitive to Van, this antibacterial nanoplatform has great potential to treat bacterial infections caused by Gram-positive pathogens.