Abstract
AbstractA wide variety of pathogens causing nosocomial infections have emerged, showing resistance towards commonly used antimicrobial agents. Nosocomial infections are rapidly emerging as a severe threat leading to high morbidity and mortality. In this study, we have introduced Vancomycin grafted polydopamine(pDA) coated silver nanoparticles (AgNPs) to combat vancomycin‐resistant bacterial species Enterococci faecalis ( E.faecalis). The prepared nanoparticles were characterized by High Resolution ‐Transmission Electron Microscopy (HR‐TEM), Energy Dispersive X‐ray Spectroscopy (EDS), Ultraviolet (UV) Visible spectroscopy and Attenuated Total Reflection‐Fourier Transform Infrared spectroscopy (ATR‐FTIR). The nanoparticles were 33 nm in size as revealed by HR‐TEM. Antimicrobial assays were conducted to investigate the antimicrobial activity of vancomycin‐pDA@AgNPs against E. faecalis by a zone of inhibition method. The vancomycin‐pDA@AgNPs exhibited good bactericidal activity against vancomycin‐resistant E. faecalis.
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