Vancomycin Associated Acute Kidney Injury: A Longitudinal Study in China.

Pan Kunming,Ding Xiaoqiang,Lv Qianzhou,Chen Zhangzhang,Li Xiaoyu,Xu Qing,Chen Can,Wu Wei

doi:10.3389/fphar.2021.632107

Abstract

Background: Vancomycin-associated acute kidney injury (VA-AKI) is a recognizable condition with known risk factors. However, the use of vancomycin in clinical practices in China is distinct from other countries. We conducted this longitudinal study to show the characteristics of VA-AKI and how to manage it in clinical practice. Patients and Methods: We included patients admitted to hospital, who received vancomycin therapy between January 1, 2016 and June 2019. VA-AKI was defined as a patient having developed AKI during vancomycin therapy or within 48 h following the withdrawal of vancomycin therapy. Results: A total of 3719 patients from 7058 possible participants were included in the study. 998 patients were excluded because of lacking of serum creatinine measurement. The incidence of VA-AKI was 14.3%. Only 32.3% (963/2990) of recommended patients performed therapeutic drug monitoring of vancomycin. Patients with VA-AKI were more likely to concomitant administration of cephalosporin (OR 1.55, 95% CI 1.08–2.21, p = 0.017), carbapenems (OR 1.46, 95% CI 1.11–1.91, p = 0.006) and piperacillin-tazobactam (OR 3.12, 95% CI 1.50–6.49, p = 0.002). Full renal recovery (OR 0.208, p = 0.005) was independent protective factors for mortality. Compared with acute kidney injury stage 1, AKI stage 2 (OR 2.174, p = 0.005) and AKI stage 3 (OR 2.210, p = 0.005) were independent risk factors for fail to full renal recovery. Conclusion: Lack of a serum creatinine measurement for the diagnosis of AKI and lack of standardization of vancomycin therapeutic drug monitoring should be improved. Patient concomitant with piperacillin-tazobactam are at higher risk. Full renal recovery was associated with a significantly reduced morality.

Highlights

Vancomycin is the first-line treatment for methicillin-resistant Staphylococcus aureus (MRSA) infections. It has been associated with significant acute kidney injury (AKI) (Chen et al, 2011; Liu et al, 2011), which is a common disorder with a high risk of mortality, the development of chronic kidney disease, and substantial medical expense (Yang et al, 2015)
Patients were excluded if 1) they had stage 5 chronic kidney disease or were receiving regular dialysis; 2) their baseline serum creatinine (SCr) was ≥4 mg/dL (353.6 μmol/L); 3) they had AKI on admission; 4) they died within 48 h of vancomycin therapy initiation; 5) there was a history of nephrectomy, kidney transplantation or solitary kidney; 6) their vancomycin administration was not intravenous; 7) they received less than four doses of vancomycin, or; 8) their SCr measurement was insufficient to determine whether AKI had developed
vancomycin-associated AKI (VA-AKI) was defined as a patient having developed AKI during vancomycin therapy or within 48 h following the withdrawal of vancomycin therapy

Summary

Introduction

Vancomycin is the first-line treatment for methicillin-resistant Staphylococcus aureus (MRSA) infections. It has been associated with significant acute kidney injury (AKI) (Chen et al, 2011; Liu et al, 2011), which is a common disorder with a high risk of mortality, the development of chronic kidney disease, and substantial medical expense (Yang et al, 2015). There are numerous potential risk factors for VA-AKI including race, obesity, vancomycin exposure, pre-existing kidney disease, severity of illness, Vancomycin Associated Acute Kidney Injury concurrent nephrotoxin exposure, concurrent piperacillintazobactam use, etc. The use of vancomycin in clinical practices in China is distinct from other countries We conducted this longitudinal study to show the characteristics of VA-AKI and how to manage it in clinical practice

Methods

Results

Discussion

Conclusion