Abstract
We examined the effects of vanadium sulfate (VOSO4) treatment at 5 and 10 mg/kg for 30 days on endocrine pancreas activity and histology in nondiabetic and STZ-induced diabetic rats. In diabetic group, blood glucose levels significantly increased while insulinemia level markedly decreased. At the end of treatment, VOSO4 at a dose of 10 mg/Kg normalized blood glucose level in diabetic group, restored insulinemia, and significantly improved insulin sensitivity. VOSO4 also increased in a dose-dependent manner the number of insulin immunopositive beta cells in pancreatic islets of nondiabetic rats. Furthermore, in the STZ-diabetic group, the decrease in the number of insulin immunopositive beta cells was corrected to reach the control level mainly with the higher dose of vanadium. Therefore, VOSO4 treatment normalized plasma glucose and insulin levels and improved insulin sensitivity in STZ-experimental diabetes and induced beta cells proliferation and/or regeneration in normal or diabetic rats.
Highlights
A notable increase of blood glucose level was observed in the STZ-treated control rats compared to untreated animals (406.25 ± 16.70 versus 99.83 ± 5.19 mg/dL) indicating diabetes installation that was maintained during all experiment
We studied the antidiabetic properties of vanadium by exploring its effects on blood glucose and insulin levels as well as B cells of endocrine pancreas
Using STZ-induced diabetic rats, we showed that treatment with vanadyl sulfate (VOSO4) at 5 and 10 mg/Kg significantly reduced the mean blood glucose levels by the 10th and 5th days, respectively, in comparison with untreated control group
Summary
Many studies were conducted on inorganic and organic vanadium derivatives in induced diabetes animal models, in which the studied compounds were found to impact the levels of glucose, cholesterol, and triglycerides, with no significant harmful side effects upon prolonged administration [3,4,5,6,7]. Many experiments were performed in diabetic patients, confirming the therapeutic effect of vanadium compounds on blood glucose levels with little toxic effects [8]. Vanadium compounds have been shown to have antidiabetic properties in STZ-induced diabetic model, the mechanism of their actions remained currently under investigation. The aim of this study was to investigate the responses of 30 days of treatment with vanadium sulfate in nondiabetic and STZ-induced diabetic rats
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