Abstract
Reaction of VO(acac)(2) with N'-(3-bromo-5-chloro-2-hydroxybenzylidene)-3-methylbenzohydrazide (H(2)L) in methanol afforded a new mononuclear vanadium(V) complex, [VOL(OMe)(MeOH)]. Structure of the complex has been characterized by physico-chemical methods and single-crystal X-ray diffraction. The complex crystallizes as the monoclinic space group P2(1)/c, with unit cell dimensions a = 13.1345(10) Å, b = 18.6279(14) Å, c = 7.8983(8) Å, β = 90.248(2)º, V = 1932.4(3) Å(3), Z = 4, R(1) = 0.0963, wR(2) = 0.2213, S = 1.113. X-ray analysis indicated that the V atom in the complex is in octahedral coordination. The insulin-like activity of the complex was studied.
Highlights
Transition metal complexes with various ligands have been received much attention because they have interesting biological activities
Oxovanadium(IV) sulphate has been demonstrated to possess oral insulin-like activity similar to that of the vanadates, with lowered toxicity.[6]
A number of low molecular weight vanadium complexes have been prepared and studied on their insulin-like activity in an attempt to improve the bioavailability of vanadium.[8]
Summary
Transition metal complexes with various ligands have been received much attention because they have interesting biological activities. -3-methylbenzohydrazide: Synthesis, Crystal Structure and Biological Activity Reaction of VO(acac)[2] with N’-(3-bromo-5-chloro-2-hydroxybenzylidene)-3-methylbenzohydrazide (H2L) in methanol afforded a new mononuclear vanadium(V) complex, [VOL(OMe)(MeOH)].
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