Van der woude syndrome: A case report and review

Abstract

Introduction: The prevalent autosomal disorder, with or without cleft palate and lip, is Van der Woude Syndrome (VWS). The condition has been known for its lower lip pits. Interferon Regulatory Factor 6 (IRF6) gene mutations are causing a range of cases of VWS. The furrows caused an accumulation of mucous and felt esthetic pain during meals and crying.Purpose: To determine VWS causes, prevalence, treatment, symptoms, and diagnosis.Case report: A six-month-old baby was with lip pits, a bilateral cleft lip and palate since birth. The extraoral exam showed bilateral pit swellings with dome form on the lower vermilion boundary laterally to the midline. Simultaneous operations with the Nordhoff technique and simple excision were conducted combined with a breakthrough procedure under general anesthesia to correct bilateral cleft lips. The patient showed better clinical condition after the seventh-day post-surgery without infection sign, and bilateral cleft in lower lip pit closed in a month after surgery.Conclusion: VWS is generally not known and not always diagnosed. It is peculiar that the cleft palate and lip phenomenon is routinely integrated into the same pedigree. The patient with a lip pit can be thoroughly examined, for example, by revealing the secret shape of the cleft. In this case, the surgical repair was handled simultaneously to both functional and esthetic aspects to achieve satisfying results.