Values of mean platelet volume in patients with chronic tonsillitis and adenoid hypertrophy

Cengiz Cevik,Ibrahim Iilfeler,Ertap Akoglu,Erhan Yengil,Ihsan Gulmez,Murat Tutanc,Ercan Akbay

doi:10.12669/pjms.292.2715

Abstract

Chronic tonsillitis (CT)-adenoid hypertrophy (AH) is the most common cause of obstructive sleep apnea (OSA), which is one of the most common reasons of nocturnal hypoxia in children. However, there is limited information about the relationship between childhood OSA and atherosclerosis or cardiac diseases. In the present study, we evaluated the relationship between mean platelet volume (MPV) and CT-AH which is the most frequent cause leading OSA in children. Methodology : The medical records of 200 children, who underwent adenoidectomy or adenotonsillectomy with a diagnosis of adenoid hypertrophy and/or chronic tonsillitis between October, 2010 and June, 2012, and 240 healthy controls were evaluated. Subjects were classified into 3 groups. Group I consisted of patients who underwent adenoidectomy, whereas Group II consisted of patients who had adenotonsillectomy. Healthy children were employed as control group. White blood cell count (WBC), platelet count (PLT), hemoglobin (Hb) levels and mean platelet volume (MPV) values were recorded individually. MPV values were 6.6±0.8, 6.6±0.7 and 7.3±0.9 in Group I, Group II and control group, respectively. It was found that MPV values in groups I and II were significantly lower than control group. There was no significant difference between group I and II. Conclusion : Obstructive sleep apnea (OSA) caused by CT-AH is associated with low MPV values in childhood.

Highlights

Adenoid-tonsil localized at oropharynx and nasopharynx is a component of Waldeyer’s tonsilar ring
A significant difference was found in platelet count (PLT) counts between control group compared to group 1 and 2 (p
There was a significant relationship between PLT counts and Hb, White blood cell count (WBC), age or mean platelet volume (MPV) values, where PLT counts were increased by increasing age, Hb levels and WBC counts

Summary

Introduction

Adenoid-tonsil localized at oropharynx and nasopharynx is a component of Waldeyer’s tonsilar ring. Tonsillitis causes fever, sore throat, dysphagia, while associated adenoid hypertrophy causes snoring, sleep with open mouth and nocturnal apnea. In children, persisting obstruction findings may cause aggressive behavior, anxiety, impaired attention, depression, somatization disorders and growth retardation at long-term.[1,2]. In USA, it is the most common operation performed at childhood period.[1] Chronic tonsillitis can cause severe stress and growth retardation as well as symptoms including sleep disorders, snoring, sleep with open mouth, dysphagia and poor appetite.[2] The etiopathogenesis of growth retardation isn’t fully understood. Implied factors include poor appetite and dysphagia causing low caloric intake, nocturnal hypoxemia and acidosis, and higher energy expenditure caused by increased respiratory effort.[3]

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