Abstract
Objective To investigate the value of uterine artery Doppler flow score combined with serum human chorionic gonadotropin (HCG) detection in early pregnancy to predict pregnancy outcome. Methods The clinical data of 895 pregnant women within 3 to 9 weeks of gestational period from January 2017 to August 2018 in Taiyuan Maternal and Child Health Hospital were selected. The uterine artery Doppler blood flow score, serum HCG level in early pregnancy and pregnancy outcomes were retrospectively analyzed. According to the outcomes of pregnancy, they were divided into abortion group, clinical prediction of fetal growth restriction (FGR) group and normal pregnancy group. Statistical analysis was performed on pulsatility index (PI), uterine artery resistance index (RI), peak systolic velocity/end-diastolic flow rate (S/D) and serum HCG levels in the FGR group and the normal pregnancy group. Serum HCG was used as a reference in comparison of the average results of 4 to 5 weeks, 5 to 6 weeks and 6 to 7 weeks of pregnancy. Results Among 895 pregnant women, 82 cases were in FGR group, 796 cases in normal pregnancy group and 17 cases in abortion group. The serum HCG level in the FGR group was significantly lower than that in the normal pregnancy group (P 0.05). The sensitivity of PI combined with early pregnancy serum HCG was 82.34%, similar to that of PI combined with serum HCG and early diastolic notch (P>0.05). Compared with pure uterine artery Doppler blood flow parameters and simple serum HCG, the sensitivity of PI combined with HCG were significantly increased (P 0.05). Conclusions Uterine artery Doppler blood flow score combined with serum HCG detection in early pregnancy has a high sensitivity in predicting pregnancy outcomes, but the specificity is not remarkable, so it can not improve the predictive efficacy of pregnancy outcome. Key words: Early pregnancy; Outcome prediction; Doppler blood flow score; Human chorionic gonadotropin
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