Abstract
Objective: To detect the changes of coagulation function in patients with early hemorrhagic shock by thromboelastography (TEG). Methods: TEG was performed in 50 patients with early hemorrhagic shock and surgical indications. The TEG parameters were compared with 50 healthy people. The coagulation and fibrinolysis in patients with early hemorrhagic shock were observed. Results: In terms of coagulation parameters, the R value decreased, the α angle increased, and the K value and MA value did not change significantly in patients with early hemorrhagic shock. Fibrinolytic aspects: EPL, LY30 observations have no significant changes compared to normal values. Conclusion: The plasma coagulation factor activity is increased in patients with early hemorrhagic shock; the fibrin level is increased; the blood is in a hypercoagulable state; and the fibrinolysis function is not changed. The timely detection of TEG can be used for coagulation function monitoring and blood transfusion therapy in patients with surgical hemorrhagic shock. It provides an important basis for preventing the formation of deep vein thrombosis.
Highlights
Hemorrhagic shock and coagulopathy caused by various causes during surgical perioperative period are serious threats to patients’ life safety
2) In terms of fibrinolysis, the EPL and LY30 observations in patients with early hemorrhagic shock did not change significantly compared with the normal values, indicating that there was no abnormality in fibrinolytic function in patients with early hemorrhagic shock (Table 2)
When the wound causes acute hemorrhage, tissue factor release, activation of coagulation factor VII initiates the exogenous coagulation process, and activates FXI, FVIII, and FV through a small amount of thrombin generated after activation, and activates the endogenous coagulation system to produce a high concentration
Summary
Hemorrhagic shock and coagulopathy caused by various causes during surgical perioperative period are serious threats to patients’ life safety. The thromboelastograph is an analyzer that monitors the coagulation process from the entire dynamic process of platelet aggregation, coagulation, fibrinolysis, etc. It was invented by the German Harter in 1948. The thromboelastogram (TEG) is a graphical display of the complete process of coagulation initiation to clot formation and fibrinolysis. TEG detection is used to determine the perioperative coagulation function and fibrinolysis status in patients with early hemorrhagic shock, which provides an important basis for blood transfusion therapy and prevention of deep vein thrombosis in patients with hemorrhagic shock
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