Abstract
Background: Increased mean platelet volume (MPV) is a central process in the pathophysiology of coronary artery disease (CAD). Objectives: To investigate whether assessment of MPV, besides the traditional risk factors, enhances the assessment process for the risk of acute coronary syndrome (ACS). Materials and Methods: This study included 81 patients, divided into 2 groups; group I included 61 patients with acute coronary syndrome (ACS); further subdivided into group I a (37 Tn +ve patients) and group I b (24 Tn -ve patients) and group II included 20 completely healthy age matched as a control group; all patients were subjected to; history taking, clinical examination, ECG, assessment of MPV and lipid profile. Results: Tn +ve ACS patients had the highest MPV (13.3 ± 2.4fL), MPV correlated significantly with total cholesterol level, LDL level, and Tn level, P<0.001). By multivariate analysis, only MPV significantly increased the probability of Tn +ve ACS development (B ± SE=0.078 ± 0.028, t=2.8, 95% CI 0.022-0.133 with an odds ratio=0.358, P=0.007). MPV of ≥11.1 fL was the best cut-off value in predicting Tn +ve ACS with a sensitivity of 84% and a specificity of 65% (P=0.000). Conclusion: Our study determined that the MPV can facilitate the risk stratification for ACS occurrence. Which could be used as an alarming sign in follow up of patients with CAD to predict those at risk of Tn +ve ACS.
Highlights
Increased mean platelet volume (MPV) is a main step in the pathophysiology of coronary artery disease [1,2,3]
A total of 81 patients were enrolled in the study; group I (n=61 acute coronary syndrome (ACS) patients) which subdivided into subgroup Ia (n=37 Tn +ve patients) and subgroup Ib (n=24 Tn -ve patients) and group II (n=20 control patients)
MPV of ≥11.1 fL was the best cut-off value considered to predict Tn +ve ACS with a sensitivity of 84% and a specificity of 65 % (P=0.000, 95% CI 0.699-0.906) done by Receiver Operating Characteristics (ROC) analysis; Figure 1
Summary
Increased mean platelet volume (MPV) is a main step in the pathophysiology of coronary artery disease [1,2,3]. MPV, is a potentially useful biomarker of platelet activity in the setting of cardiovascular disease, as it is a major culprit in atherothrombotic events [4,5]. Platelet volume and its activity had a major role in the atherothrombotic process that was reinforced by the fact that antiplatelet drugs can reduce cardiovascular events [6]. Measuring platelet activity by any of a wide variety of methods has been reported to identify individuals at increased risk for cardiovascular events, but it remains a research tool that is yet to be included in routine clinical decision-making. Increased mean platelet volume (MPV) is a central process in the pathophysiology of coronary artery disease (CAD)
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