Abstract
Objective To see whether serum glycocholic acid (CG) and total bile acids (TBA) can predict maternal and perinatal outcomes in pregnant women with intrahepatic cholestasis (ICP). Method The observation group consisted of 80 women with ICP who were treated in our hospital, whereas the control group consisted of 50 ordinary women who were also treated at our hospital at the same time. The levels of CG and TBA in the two groups were determined independently, and the differences in poor perinatal outcomes were compared. Finally, the predictive diagnostic value of CG and TBA for poor perinatal outcomes in ICP mothers was displayed using the Spearman correlation between CG and TBA and Apgar. The maternal CG and TBA levels in the observation group were substantially higher than in the control group (P0.05). The observation group had more significant maternal-fetal discomfort, neonatal asphyxia, preterm birth, and perinatal death than the control group (P0.05). The risk of poor perinatal outcomes in ICP mothers rose when TBA and CG levels increased (P0.05). Apgar ratings were inversely associated with CG and TBA (r = −0.8251 and r = −0.5969, respectively, P0.05). The CG and TBA diagnostic AUCs for unfavorable perinatal outcomes in ICP mothers were (P0.05). Conclusion CG and TBA have a high diagnostic value for ICP and may better predict and identify poor prenatal outcomes. It is suitable for clinical use.
Highlights
Intrahepatic cholestasis of pregnancy (ICP) is a unique complication of pregnancy with typical symptoms such as pruritus, jaundice, and altered liver function [1]
Clinical studies have shown that the incidence of preterm delivery in ICP mothers is about 19%–60%, the rate of fecal contamination of the amniotic fluid is 17%–24%, the rate of fetal asphyxia is 22%–41%, and the rate of stillbirth is as high as 25% [3, 4]
Other studies have pointed out that the preterm birth rate and the incidence of adverse perinatal outcomes in women with ICP are significantly higher than those in ordinary women, which can seriously impact the average growth and development of the perinatal infant [5]. e pathogenesis of ICP is currently unclear, and studies have recognized that abnormal estrogen metabolism, genetics, environment, immune dysfunction, and drugs may be associated with the development of ICP [6]
Summary
To see whether serum glycocholic acid (CG) and total bile acids (TBA) can predict maternal and perinatal outcomes in pregnant women with intrahepatic cholestasis (ICP). The predictive diagnostic value of CG and TBA for poor perinatal outcomes in ICP mothers was displayed using the Spearman correlation between CG and TBA and Apgar. E maternal CG and TBA levels in the observation group were substantially higher than in the control group (P0.05). E risk of poor perinatal outcomes in ICP mothers rose when TBA and CG levels increased (P0.05). E CG and TBA diagnostic AUCs for unfavorable perinatal outcomes in ICP mothers were (P0.05). CG and TBA have a high diagnostic value for ICP and may better predict and identify poor prenatal outcomes.
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
