Value of serum CA125 level to the prognosis of epithelial ovarian cancer

Abstract

Objective To explore the value of serum CA125 level to the prognosis of epithelial ovarian cancer. Methods The clinicopathologic data and serum CA125 level of 76 patients with epithelial ovarian cancer from Jan. 2003 to Dec. 2009 were analyzed retrospectively, and the outcomes of patients were followed up. Results No relationship was found between CA125 concentration before therapy with prognosis and cytoreductive condition for epithelial ovarian cancer. The normal or abnormal CA125 concentration after 3 courses of treatment meant different prognosis, with the 5-year survival rates of 63.8 % and 25.0 %, and the median survival time of 57 months and 28 months, respectively (χ2 = 19.951, P= 0.000). The 5-year survival rates of patients with CA125 concentration≤10.0 U/ml and>10.0 U/ml after therapy were 72.7 % and 42.8 %, respectively (χ2 = 7.266, P= 0.007). According to multivariate Cox proportional-hazard model, two independent factors , operative-pathological staging and CA125 concentration after 3 courses, were related significantly to the prognosis of epithelial ovarian cancer (P< 0.05). Conclusion Serum CA125 level, especially after 3 courses and therapy, plays an important role in the prognosis of epithelial ovarian cancer. Key words: Ovarian neoplasms; CA125; Prognosis