Value of Prognostic Nutritional Index on Complications After Radical Cystectomy and Ileal Conduit: Retrospective Clinical Research

Abstract

Objective: Prognostic nutritional index (PNI) is a method that can be easily calculated according to the serum albumin level and lymphocyte count and shows the nutritional and immune status of patients. PNI was originally developed as an indicator of the preoperative nutritional status of patients with gastrointestinal malignancies. The aim of this study is to evaluate the value of PNI in prediction of postoperative complications after radical cystectomy and ileal conduit. Material and Methods: We conducted a retrospective study of patients who underwent radical cystectomy and ileal conduit between 2011 and 2021. A total of 174 patients were included in this study. The patients were divided into 2 groups according to the cutoff value of the PNI: those with a PNI≥46 (normal group) and those with a PNI<46 (low PNI group). The clinicopathological features between the 2 groups were compared using the χ2 test. Results: A total of 174 radical cystectomy with ileal conduit patients were available for analysis. The cohort included 140 males and 34 females. Overall, 36 (20.6%) patients encountered a Grade ≥ III complication after surgery. In the normal group, 9 (17.5%) of patients had Grade ≥ III complication and 27 of patients (34.04%) in low PNI group had Grade ≥ III complication after surgery. When the groups were compared in terms of major complication rates, there were statistically significant more Grade ≥ III complications in the low PNI group (p<0.001). Conclusion: PNI can be used clinically to predict the possibility of serious postoperative complications in patients who are candidates for radical cystectomy.