Value of platelet indices in identifying complete resolution of thrombus in deep venous thrombosis patients.

Abstract

We aimed to evaluate whether mean platelet volume (MPV) and platelet distribution width (PDW) are helpful to identify complete thrombus resolution (CTR) after acute deep venous thrombosis (DVT). Patients who had first-time episode of acute proximal DVT were included in this retrospective study. 100 patients with DVT were divided into two groups according to absence (group 1; n=68) or presence (group 2; n=32) of CTR on doppler ultrasonography at month 6. There were no significant difference in admission MPV and PDW levels between group 1 and group 2. MPV (p=0.03) and PDW (p<0.001) levels at month 6 were significantly higher in group 1 than in group 2. CTR showed a moderate negative correlation with PDW at month 6 (ρ=-0.47) and a weak negative correlation with MPV at month 6 (ρ=-0.26). Logistic regression analysis showed that PDW (OR, 2.2; p=0.004) at month 6 was an independent risk factor for the presence of residual venous thrombosis in DVT patients. Receiver operating characteristics analysis revealed that a 8.4% decrease in admission MPV at month 6 provided 62% sensitivity and 62% specificity (AUC: 0.64) and a 15.4% decrease in admission PDW at month 6 provided 87% sensitivity and 94% specificity (AUC: 0.89) for prediction of CTR in DVT patients. Percent change in admission MPV and PDW levels at month 6 may be used to identify the patients with CTR after a first episode of acute proximal DVT.