Abstract
No attempt will be made to discuss all conditions in which pituitary gland substance has been recommended, but only those in which its value has been proved, or disturbances in which, from a physiologic standpoint, such treatment is indicated. It has been definitely determined that the polyuria of diabetes insipidus can be controlled by the hypodermic administration of posterior lobe extract. The cure is purely symptomatic and continues only as long as the treatment is administered. There is evidence that similar results may be obtained by applying the solution to the nasal mucosa and, in some cases at least, by rectum; but when given by rectum the effect is very transitory. The administration by mouth is without effect in diabetes insipidus. An extract of the posterior lobe when administered hypodermically is of value in some forms of flatulence, when not due to obstruction, and in postoperative paralytic ileus. In a
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