Value of MRI elastography combined with serological markers in diagnosis of hepatitis B liver fibrosis

Abstract

Objective To investigate the value of magnetic resonance imaging (MRI) elastography combined with serological markers in diagnosis of hepatitis B liver fibrosis. Methods Sixty-six patients with hepatitis B liver fibrosis treated in Heilongjiang Provincial Hospital from January 2017 to December 2017 were selected as research objects. All patients were determined by liver bispsy, and underwent hyaluronic acid (HA) test, procollagen Ⅲ (PCⅢ) test, IV collagen (IV-C) test, laminin (LN) test and MRI elastography to compare diagnosis accuracy of these methods. Results The diagnostic accuracy of serological markers, such as HA, PCⅢ, IV-C and LN, was 80.3%, and diagnostic accuracy of MRI elastography was 81.8%, and it was 93.9% of combination method. There was no significant difference in diagnostic accuracy between single serological markers test and single MRI elastography (P>0.05), but the diagnostic accuracy of MRI combined with serological markers was significantly higher than single tests (P<0.05). Severity of liver fibrosis was positively correlated with MRI elasticity value (P<0.05); MRI result was negatively correlated with serological markers, such as HA, PCⅢ, IV-C and LN (P<0.05). Conclusions Serological markers combined with MRI elastograohy is superior to single tests in the diagnosis of liver fibrosis, which is worthy of further promotion in clinical. Key words: Hepatitis B liver fibrosis; Serological markers; Magnetic resonance imaging