Abstract
This paper aimed to explore the clinical value of combined adoption of magnetic resonance diffusion tensor imaging (DTI) and quantitative electroencephalogram (QEEG) in assessing microstructure changes and mild neurocognitive dysfunction in patients with white matter demyelination. 128 cases of white matter demyelination admitted to the hospital from October 2018 to October 2019 were rolled into the research group, and 100 healthy patients physically examined during the same period were rolled into the control (ctrl) group. QEEG and magnetic resonance DTI examinations were performed for all patients. The wave power of δ, θ, α, and β and the ratio of α/θ and (δ + θ)/(α + β) were recorded. The FA values of white matter fibers in different brain areas were measured, and the Montreal Cognitive Assessment (MoCA) and Addenbrooke Cognitive Evaluation rating (ACE-R) were adopted to assess the neurocognitive function of patients. It was found that the dominant frequency of each brain area in the research group was 8-9 Hz slow α wave. In contrast with the ctrl, the α wave and α/θ values in the research group were lower, while θ wave and δ + θ/α + β values were higher (P < 0.05); the scores of ACE-R and MoCA were lower (P < 0.01); the fractional anisotropy (FA) values of the right frontal lobe white matter (0.335 ± 0.068), the left temporal lobe white matter (0.391 ± 0.032), and the corpus callosum knee white matter (0.658 ± 0.053) were lower (P < 0.05). The FA values of these three areas were positively correlated with attention and calculation, memory, and memory of MoCA scale, respectively (P < 0.05). The FA value of the right frontal white matter was positively correlated with the attention and calculation score of the ACE-R scale (P < 0.05). In conclusion, magnetic resonance DTI combined with QEEG could reflect the microstructural changes of white matter, which may be associated with mild neurocognitive impairment. The primary objective of the study was to explore the clinical value of combined adoption of magnetic resonance DTI and QEEG in assessing microstructure changes and mild neurocognitive dysfunction in patients with white matter demyelination, expected to provide a theoretical basis for the treatment of white matter demyelination.
Highlights
White matter lesions mostly occur in the elderly over 50 years old, and their imaging examinations usually show white matter hyperintensity [1]. e causes of white matter mainly include genetics, hydrocephalus, poisoning, infection, and other factors
General Data of Research Subjects. 128 cases of white matter demyelination, admitted to our hospital from October 2018 to October 2019, were rolled into the research group, and 100 healthy patients during the same period were rolled into the ctrl
There were 78 males and 50 females; in the ctrl, there were 62 males and 38 females; and there were no obvious differences between the two groups (P > 0.05). is experiment has got permission from the ethics committee of our hospital, and the patients included in the study were aware of and agreed to it (Table 1)
Summary
White matter lesions mostly occur in the elderly over 50 years old, and their imaging examinations usually show white matter hyperintensity [1]. e causes of white matter mainly include genetics, hydrocephalus, poisoning, infection, and other factors. Demyelination, cell edema and apoptosis, axon damage, and glial cell proliferation all can cause white matter lesions [2]. E white matter demyelination is a secondary manifestation of neurological diseases such as senile degenerative changes and ischemic infarction. Studies have shown that the white matter can cause cognitive dysfunction, and if the disease is serious, it may develop into dementia [4, 5]. Because the white matter demyelination has a strong volatility, usually there is a recurrence. It may cause human dysfunction, which in turn makes the condition worse. Erefore, early diagnosis and early treatment is required for white matter demyelination, and timely diagnosis can improve the prognosis, thereby reducing the pain of the disease and prolonging the survival time It may cause human dysfunction, which in turn makes the condition worse. erefore, early diagnosis and early treatment is required for white matter demyelination, and timely diagnosis can improve the prognosis, thereby reducing the pain of the disease and prolonging the survival time
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