Abstract
Objective To determine the value of lymph node ratio (LNR) in prognosis of patients with intrahepatic cholangiocarcinoma (ICC). Methods The pathological and survival data of ICC patients were extracted from the Surveillance Epidemiology and End Result Database (SEER). The value of LNR in prognosis of patients with intrahepatic cholangiocarcinoma was evaluated by the Kaplan-Meier and Cox proportional hazard models. Results A total of 357 pathologically confirmed ICC patients were included in this study (158 males, 199 females). The results showed that patients with lymph node metastasis had significantly shorter survival time than patients without metastasis [(41.6 ± 1.8) vs. (23.2 ± 2.2) months, P<0.05]. Multivariate analysis on survival showed that the status of lymph node metastasis was independent prognostic factor of survival, after adjusting for age, gender and tumor stage. Only a LNR ≥ 20% was an independent risk factor of prognosis (HR=2.3, 95%CI: 1.4~3.8, P<0.05). Conclusion A positive lymph node ratio was superior to lymph node metastasis in predicting survival in patients with intrahepatic cholangiocarcinoma. Key words: Intrahepatic cholangiocarcinoma; Lymph node ratio; Survival time; Lymph node metastasis
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