Value Of Laboratory Tests And C - Reactive Protein In The Detection Of Neonatal Sepsis

Abstract

Method: the medical records of 200 infants, aged <30 days, with suspected infection, who where admitted in Mostafakhomeini hospital in Tehran, where reviewed retrospectively. Based on clinical and biological findings, diagnoses were categorized in to 3 groups as follow: A: proven sepsis with positive blood culture. B: probable sepsis with negative blood culture but laboratory consist with sepsis C: clinically sepsis with out any positive culture or laboratory abnormalities. The validity of laboratory tests which had performed as sepsis work-up, were compared against positive blood culture as gold standard test. Results: of 200 infants 19(9.5%) had positive blood culture. The most common causative organisms were klebsiella (5) staphylococous aurous (5) and staph Coagolase negative (5). Among laboratory tests, CRP had the best sensitivity (79%) and negative predictive value (97%) ,but poor positive predictive value (36%), the specificity of it was 85%. Conclusion: no laboratory tests alone can be used as early detection of septicemia accurately.