Value of gallbladder length-to-width ratio for diagnosis of biliary atresia by correlation with age.

Abstract

The objective is to explore the correlation between ultrasonic gallbladder length-width ratio (LTWR) and age, and the value of differential diagnosis between biliary atresia (BA) and other hepatic cholestasis. From January 2016 to June 2022, thedata of 183 patients with jaundice whounderwentabdominal ultrasound and surgical exploration in the Affiliated Hospital of Zunyi Medical Universitywereanalyzed retrospectively. The demographic data, liver function, and ultrasonic parameters were recorded and analyzed. There were statistically significant differences between BA group and non-BA group in maximum length, maximum width and LTWR of gallbladder (P < 0.001). In all age groups (I: ≤ 30days; II: 31-60days; III: 61-90days; IV: 91-120days; V: ≥ 121days), in which group III (61-90days) had the highest area under the curve (AUC) of 0.843, and group V (≥121days) had the lowest AUC of 0.548. The sensitivity, specificity, positive predictive value, negative predictive value and accuracy of gallbladder LTWR > 3.26 for BA in group II (31-60days) were 78.9%, 75.0%, 75.0%, 78.9% and 76.9%, respectively. The sensitivity, specificity, positive predictive value, negative predictive value and accuracy of gallbladder LTWR > 3.69 for BA in group III (61-90days) were 76.6%, 84.6%, 92.5%, 59.5% and 78.9%, respectively. UltrasonographyLTWRofgallbladder has certain value in the diagnosis of BA. Thediagnosticvalueof gallbladder LTWR in infants with different ages was quite different, and itwas relatively high in infantswith31-90days.